The following article illustrates how to apply certain policies (eg: disable access to local drive, printers, clipboard etc..) for users connecting from home (through Citrix Netscaler / Access Gateway)
Ensure xendesktop controllers configured to trust requests sent to the Citrix XML service. This can be done by executing the following powershell command on the each controller
Set-BrokerSite -TrustRequestsSentToTheXmlServicePort $true
Set Netscaler / Access Gateway as the point of authentication for your XenDesktop Web site.
Secure Access with Gateway Direct – CTX121360
I tested this approach by creating two policies
1) WAN with Priority 1 and only applied to Access Gateway connections
2) Unfiltered with Priority 2
policy 1 had Extra Color Compression Enabled while Policy 2 had Extra Color Compression disabled
The policy worked as expected, when connected via Netscaler it had Extra Color Compression enabled and was disabled when connected internally.
A step further
Even more granular control over policies can be achieved by utilizing Access Gateway Session policies, refer to the following link for more information